Drug Index

Palonosetron

 
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Mechanism :

Palonosetron is a selective 5-HT3 receptor antagonist, acting both peripherally and centrally.


Indication :

• To prevent chemotherapy induced nausea and vomiting


Contraindications :

Known hypersensitivity to palonosetron or any component of the formulation.


Dosing :

>1 month: 20 mcg/kg IV infusion over 15 minutes, starting half hour before chemotherapy. Max: 1.5 mg/dose.


Adverse Effect :

Prolonged QT interval, constipation, diarrhea, confusion, headache, blurred vision, anxiety, dizziness, faintness, or light-headedness, weakness, chest pain or discomfort, irregular heartbeats, shortness of breath, sweating, tiredness or weakness, pruritis, hyperkalemia, increased LFT.


Interaction :

Serotonin Modulators: Antiemetics (5HT3 Antagonists) may enhance the serotonergic effect of Serotonin Modulators resulting in serotonin syndrome.
Tramadol: Antiemetics (5HT3 Antagonists) may diminish the analgesic effect of Tramadol.


08/11/2019 21:00:27 Palonosetron
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