Drug Index

Diphenhydramine

 
print

Mechanism :

Diphenhydramine is an antihistamine with anticholinergic and sedative side effects. Antihistamines appear to compete with histamine for cell receptor sites on effector cells.


Indication :

• Sedation

• Allergic Rhinitis

• Dystonic reactions

• Motion Sickness

• Allergic reactions


Contraindications :

Hypersensitivity to diphenhydramine hydrochloride and other antihistamines of similar chemical structure. This drug should not be used in new-born or premature infants.


Dosing :

2-6 years: 6.25 mg orally every 4 to 6 hours, not to exceed 37.5 mg/24 hours.

6-12 years: 12.5 to 25 mg orally every 4 to 6 hours, not to exceed 150 mg/24 hours.

>12 years: 25 to 50 mg orally every 4 to 6 hours, not to exceed 300 mg/24 hours.


Adverse Effect :

Chills, dryness of mouth, nose, and throat, hypotension, headache, palpitations, tachycardia, hemolytic anemia, thrombocytopenia, agranulocytosis, sedation, dizziness, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, blurred vision, diplopia, vertigo, tinnitus, anorexia, nausea, vomiting, urinary frequency, urinary retention, early menses.


Interaction :

Alcohol and other CNS depressants: Diphenhydramine hydrochloride has additive effects.
MAO inhibitors: Prolong and intensify the anticholinergic effects of antihistamines.


08/11/2019 20:45:40 Diphenhydramine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0