Drug Index

Cyclizine

 
print

Mechanism :

Cyclizine is a piperazine derivative with histamine H1-receptor antagonist (antihistamine) activity. The precise mechanism of action in inhibiting the symptoms of motion sickness is not well understood. It may have effects directly on the labyrinthine apparatus and on the chemoreceptor trigger zone. Cyclizine exerts a central anticholinergic (antimuscarinic) action.


Indication :

• Vomiting

• Motion sickness

• Meniere disease

• Vestibular vertigo


Contraindications :

Cyclizine should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal tract and hepatic disease. Dose reduction may be necessary in renal impairment, in epilepsy and severe heart failure. Cyclizine injection may have a hypertensive effect.


Dosing :

6-12 years: Oral 25 mg/dose upto 3 times a day, maximum dose: 75 mg/day.

>12 years: 50 mg oral upto 4 times a day 30 min before travel, maximum 200 mg/24 hours.


Adverse Effect :

Drowsiness, occasional dry mouth, blurred vision, headache, psychomotor impairment, anti-muscarinic effects such as urinary retention and gastrointestinal disturbance, urticaria, drug rash, tachycardia, restlessness, nervousness, insomnia and hallucinations.


Interaction :

CNS Depressants: There may be additive effects with the co-administration.
Anticholinergic drugs: Side-effects enhanced.
Tricyclics, Antimuscarinics, Anxiolytics and Hypnotics: Increased antimuscarinic and sedative effects.


08/11/2019 20:49:05 Cyclizine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0