Drug Index


Mechanism :

Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.

Indication :

  • Insomnia

Contraindications :


Dosing :

<12 years:
Not recommended
>12 years:
25 mg orally 30 min before bedtime.

Adverse Effect :

Minor anticholinergic effects.

Interaction :

Monoamine Oxidase Inhibitors (MAOIs): Prolong and intensify the anticholinergic (drying) effects of antihistamines.

Hepatic Dose :

Dosage reduction may be required as it metabolised in the liver.
01/21/2024 10:29:55 Doxylamine
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