Pentazocine
Mechanism :
It is an opioid analgesic drug used in the treatment of moderate to severe pain and also as a pre-anesthetic agent. Long term use may cause physical and psychological dependency.
Indication :
- Relief for moderate to severe pain
- Pre-operative sedation
- Supplement to surgical anaesthesia
Contraindications :
Hypersensitivity to pentazocine or any component.
Dosing :
>1 year:
0.5 mg/kg IM.
Adverse Effect :
Nausea, vomiting, dizziness, sedation, psychic disturbances. Rapid injection may cause respiratory and cardiac depression.
Interaction :
Morphine: May potentiate or reduce analgesic effect of opiate agonist (i.e. morphine) depending on patients’ tolerance to opiates.
CNS depressants: Additive effects seen with other CNS depressants.
Hepatic Dose :
Usage with caution is recommended, dose may need to be reduced due to decreased hepatic metabolism and increased risk of adverse effects. However, guidelines do not specify dose.