Drug Index

Timolol Maleate

 
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Mechanism :

It is a beta-adrenergic blocking agent. It increases the drainage of the ocular fluid from the eye, thereby lowering the intraocular pressure. It is used as ophthalmic drops in the treatment of chronic glaucoma.


Indication :

• Ocular hypertension

• Open-angle glaucoma


Contraindications :

Severe chronic obstructive pulmonary disease (COPD) or a history of asthma.

Moderate to severe heart block, heart failure, or an unusually slow heartbeat.

Shock caused by severe heart problems.

If on another beta blocker.


Dosing :

Initial dose: Instill 1 drop (0.25% solution) in the affected eye(s) twice daily.

Maintenance dose: If response is unsatisfactory, may change to 0.5% solution. If satisfactory response is maintained, may decrease dose to once daily.


Adverse Effect :

Severe chronic obstructive pulmonary disease (COPD) or a history of asthma.

Moderate to severe heart block, heart failure, or an unusually slow heartbeat.

Shock caused by severe heart problems.

If on another beta blocker.

Burning sensation/stinging, blurred vision, hypotension and lowering of heart rate.


Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function. Start with lowest dose and titrate according to response
<10Dose as in normal renal function. Start with lowest dose and titrate according to response

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in GFR=10–20 mL/min

Hepatic Dose :

Dose adjustment may be required, as the drug is metabolized in the liver.
05/26/2020 03:46:56 Timolol Maleate
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