Discussion :
Thrombocytopenia is a known complication in patients infected with HIV-1. However, the exact immune mechanism leading to platelet destruction is unclear. Elevated levels of antiplatelet IgG antibodies and non-specific deposition of circulating immune complexes and complements have been suggested as the cause of increased clearance of platelet. However studies have depicted that increased levels of anti platelet IgG antibodies are not causally related to the development of thrombocytopenia in children. With evidence of viral RNA present in megakaryocytes, a direct role of HIV in the pathophysiology of thrombocytopenia may be present. ART can help to increase the platelet count as is seen in this patient
E-published: August 2012 Vol 9 Issue 8 Art No. 53
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