ISSN - 0973-0958

Pediatric Oncall Journal View Article

Autoimmune Liver Disease In Children
Aarti Rahangdale.
Consultant Pediatrician, Aadhya Multispecialty Hospital, Gondia, Maharashtra, India.
Abstract
Autoimmune hepatitis (AIH) is characterized by inflammatory liver histology, circulating-non-organ specific autoantibodies and increased level of transaminases and serum immunoglobulins in absence of a known etiology. Two types of AIH have been described – Type-1 AIH which has positive smooth muscle antibody (SMA) and/or antinuclear antibody (ANA) & Type-2 AIH which has antibodies to liver-kidney microsomal (anti-LKM). Both types have female preponderance. We report a series of 6 patients (5 girls, 1 boy) with AIH (5 Type-1 AIH & 1 Type-2 AIH) who had varied presentations (5 patients presented with jaundice of which 4 patients had acute symptoms and one had jaundice for 2 months. Two patients had recurrent episodes of jaundice and one patient with Type-2 AIH had failure to thrive with hepatosplenomegaly and alopecia partialis). Three patients with AIH Type-1 were treated with oral prednisolone and had normalization of liver enzymes within 6 months of therapy and are in remission. Remaining 3 patients refused treatment. All other causes of liver disease including viral hepatitis, Wilson’s disease were ruled out in these patients.

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