ISSN - 0973-0958

Pediatric Oncall Journal View Article

Paradoxical Upgradation Reaction (PUR) In Disseminated Tuberculosis in Takayasu Arteritis
R Chanchlani1, S Anand2, J Valecha3, V Gupta2, S Goyal2, A Tiwari2.
1Department of Surgery, Chirayu Medical College & Hospital, Bhopal, Madhya Pradesh, India,
2Department of Pediatrics, Chirayu Medical College & Hospital, Bhopal, Madhya Pradesh, India,
3Department of Radiodiagnosis, Chirayu Medical College & Hospital, Bhopal, Madhya Pradesh, India.
Paradoxical tuberculous reaction is defined as documented worsening of pre-existing tuberculous lesions or the development of new lesions during appropriate anti-tuberculous treatment (ATT) after an initial response to treatment and that is temporally related to recovery of the immune system. We treated a case of such a paradoxical reaction in an 11 years old girl who was diagnosed a case of Takayasu Arteritis with renal TB and was being treated with ATT. On follow up after 6 weeks, she developed multiple intracranial tuberculomas and hydrocephalus. She improved after additional treatment with corticosteroids.

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