Drug Index



Mechanism :

Ceftriaxone is a semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.

Indication :

• Meningitis

• Typhoid

• Pneumonia

• Otitis media

• Pyelonephritis

• Pelvic infections

• Septicaemia

• Gonococcal infections

• Septicemia

Contraindications :

Ceftriaxone is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Dosing :

50-100 mg/kg/day IV divided in 12 hourly doses for 7-14 days. Maximum dose: 4 g/day.

In meningitis use 100 mg/kg/day.

Adverse Effect :

Injection site inflammation, rash, pruritus, fever, eosinophilia, urticaria, anaphylaxis, colitis, diarrhea, nausea, and vomiting, pseudomembranous colitis.

Interaction :

Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.
Positive direct Coombs tests have been reported during treatment with the cephalosporin antibiotics.

03/14/2020 10:15:31 Ceftriaxone
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