Drug Index

Ceftriaxone

 
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Mechanism :

Ceftriaxone is a semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.


Indication :

• Meningitis

• Typhoid

• Pneumonia

• Otitis media

• Pyelonephritis

• Pelvic infections

• Septicaemia

• Gonococcal infections

• Septicemia


Contraindications :

Ceftriaxone is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.


Dosing :

50-100 mg/kg/day IV divided in 12 hourly doses for 7-14 days. Maximum dose: 4 g/day.

In meningitis use 100 mg/kg/day.


Adverse Effect :

Injection site inflammation, rash, pruritus, fever, eosinophilia, urticaria, anaphylaxis, colitis, diarrhea, nausea, and vomiting, pseudomembranous colitis.


Interaction :

Increased nephrotoxicity has been reported following concomitant administration of cephalosporins and aminoglycoside antibiotics.
Positive direct Coombs tests have been reported during treatment with the cephalosporin antibiotics.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function. Maximum 2 g daily

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. 2 g every 12–24 hours
CVVHD/HDFLikely dialysability. 2 g every 12–24 hours

Hepatic Dose :

No dosage adjustments are recommended. Dose adjustment may be required with both hepatic dysfunction and significant renal impairment.
05/21/2020 22:40:25 Ceftriaxone
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