Question :
Posted On : 15 Oct 2015
REGARDING BUCLIZINE-

WHAT IS THIS MOLECULE_?
IS IT PROPER MOLECULE TO PRESCRIBE AS AN APPETIZER_?
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Expert Answer :
Buclizine is an antihistaminic and anticholinergic. It is a Piperazine derivative. Its IUPAC name is {RS}-1-{{4-chlorophenyl}- phenyl-methyl}-4- {{4-tert-butylphenyl} methyl} piperazine, C28H33ClN2 .

It is mainly used as an antiemetic. It has also been used for appetite stimulation. Its mechanism of action for appetite stimulation and weight gain is not known. It is postulated that it causes mild hypoglycemia which may stimulate hunger. Also, it acts on the central Ach receptors, thereby affecting hunger.

Buclizine, is highly lipophilic. If taken for long duration for appetite stimulation, it’s entry into CNS can cause increased drowsiness.

It has been withdrawn from the market as an appetite stimulant.
Answer Discussion :
No answer discussion available.




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