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Posted On : 27 Apr 2025

Why the dose of Piperacillin alone is 100 mg/kg and the dose of Piperacillin with tazobactam 300-400mg/kg?

Expert Answer :

Answer Discussion :

G

Gladys Yonah

0

the 200mg is added for tazobactam

26 Days ago

T

Tanveer Ahmad

0

don't know why

26 Days ago

B

Bushra Khaan

6

Because tazobactam increases its clearance

26 Days ago

Answer 1

Piperacillin dose is Neonates Less than 7 days: 150 mg/kg/day IM, IV in 3 divided doses, neonates More than 7 days: 200 mg/kg/day IM, IV in 4 divided doses. Infants and children: 200-300 mg/kg/day IV/IM in divided doses q 4-6. (Max 24g/day)

For Piperacillin tazobactum
Dosing is based on the Piperacillin component.
Infants Less than 6 months: 150 – 300 mg/kg/day IV in 3-4 divided doses, infants More than 6 months and children: 240 mg/kg/day IV in 3 divided doses. For serious pseudomonal infections dose of 300-400 mg/kg/day in 4 divided doses has been used (max 18 g Piperacillin component, day)

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