Drug Index

Bupropion

 
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Mechanism :

Bupropion is a relatively weak inhibitor of the neuronal uptake of norepinephrine, serotonin, and dopamine, and does not inhibit monoamine oxidase.


Indication :

• Attention deficit hypersensitivity disorder


Contraindications :

Contraindicated in patients with a seizure disorder, in patients with a current or prior diagnosis of bulimia or anorexia nervosa, in patients undergoing abrupt discontinuation of alcohol or sedatives, and in patients who have shown an allergic response to bupropion.


Dosing :

Oral: 6-18 years of age: Initial: 3 mg/kg/day or 150 mg/day. Can increase to 6 mg/kg/day or 300 mg/day in 2-3 divided doses.


Adverse Effect :

Dry mouth, tinnitus, insomnia, sweating, anorexia, skin rash and light headedness.


Interaction :

MAO Inhibitors: The acute toxicity of bupropion is enhanced by the MAO inhibitor phenelzine.
Levodopa and Amantadine: Higher incidence of adverse effects is seen.
Drugs that Lower Seizure Threshold: Antipsychotics, antidepressants, theophylline, systemic steroids, etc should be undertaken only with extreme caution.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50150 mg daily
10-20150 mg daily
<10150 mg daily

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxNot dialysed. Dose as in GFR<10 mL/min
CAV/VVHDUnlikely to be dialysed. Dose as in GFR=10–20 mL/min

Hepatic Dose :

Moderate to severe hepatic impairment: Start therapy at a lower dosage and do not exceed 75 mg/day PO.
Mild hepatic impairment: Use dose at reduced level.
05/28/2020 23:44:29 Bupropion
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