Drug Index

Trimipramine

 
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Mechanism :

Trimipramine is an antidepressant with an anxiety-reducing sedative component to its action. The mode of action on the central nervous system is not known. However, unlike amphetamine-type compounds it does not act primarily by stimulation of the central nervous system. It does not act by inhibition of the monoamine oxidase system.


Indication :

• Depression

• Nocturnal enuresis


Contraindications :

Trimipramine is contraindicated in patients who have shown prior hypersensitivity to it and in acute porphyria, hepatic impairment and cardiovascular disease.


Dosing :

>12 years: 50 mg initially. Max: 100 mg/day.


Adverse Effect :

Mainly anticholinergic effects, sedation, postural hypotension, tremor, sweating, arrhythmia, increased appetite and weight gain, sexual dysfunction and lowered seizure threshold.


Interaction :

MAOIs: Hyperpyretic crises, severe convulsions, and deaths have occurred in patients receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously
OCPs, Calcium Channel Blockers, Cimetidine, Phenothiazines, SSRIs: Plasma concentration of trimipramine increased.
Rifampicin, Anti-Coagulants: Decreased plasma concentration of trimipramine.
Sedatives, hypotensives, drugs that prolong QT interval: Increased effects of these drugs.


07/18/2019 02:28:59 Trimipramine
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