Drug Index

Trazodone

 
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Mechanism :

It is an atypical antidepressant used in the treatment of obsessive-compulsive disorders, antidepressants and phobias. It is used in children more than 6 years of age.


Indication :

• Treatment of depression


Contraindications :

Do not use trazodone if you have taken a MAO inhibitor in the past 14 days; Hypersensitivity; Some young people have thoughts about suicide when first taking an antidepressant.


Dosing :

6 to 12 years: Initial dose: 1.5 to 2 mg/kg/day PO in divided doses. May increase up to 6 mg/kg/day in 3 divided doses.

>12 years to 18 years: Initial dose: 25 to 50 mg per day. May increase up to 100 to 150 mg per day in divided doses.

Trazodone should be taken shortly after a meal or light snack.


Adverse Effect :

Headache, confusion, dizziness, dry mouth, nausea, vomiting, fatigue, constipation, blurred vision.


Interaction :

Amitriptyline: Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Buspirone: Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Carbamazepine: The CYP3A4 inducer, Carbamazepine, may decrease Trazodone efficacy by increasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Carbamazepine is initiated, discontinued or dose changed.
Cimetidine: The CYP3A4 inhibitor, Cimetidine, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Monitor for changes in Trazodone efficacy/toxicity if Cimetidine is initiated, discontinued or dose changed.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function. Start with small doses and increase gradually
<10Start with small doses and increase gradually DOSE IN PATIENTS

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in GFR=10–20 mL/min

Hepatic Dose :

Dose adjustment guidelines are not available. Use cautiously. Dose reduction may be needed as the drug has extensive hepatic metabolism.
06/01/2020 07:22:49 Trazodone
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