Drug Index



Mechanism :

Clomipramine is a tricyclic anti-depressant. The clinical effect is due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings.

Indication :

• Depression

• Obsessive compulsive disorder

Contraindications :

Clomipramine is contraindicated in patients who have shown prior hypersensitivity to it and in acute porphyria, hepatic impairment and cardiovascular disease.

Dosing :

<10 years: Safety and efficacy not established.

≥10 years: Initially 25 mg/day PO and gradually increase up to 100 mg/day or 3 mg/kg/day, whichever is less. Usually as single dose at bedtime but may be given in divided doses.

Adverse Effect :

Mainly anticholinergic effects, nausea, constipation, sedation, postural hypotension, tremor, sweating, arrhythmia, increased appetite and weight gain, sexual dysfunction and lowered seizure threshold.

Interaction :

MAOIs: Hyperpyretic crises, severe convulsions, and deaths have occurred in patients receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously.
Oral Contraceptives, Calcium Channel Blockers, Cimetidine, Phenothiazines, SSRIs: Plasma concentration of clomipramine increased.
Rifampicin, Anti-Coagulants: Decreased plasma concentration of clomipramine.
Sedatives, Hypotensives, drugs that prolong QT interval: Increased effects of these drugs.

03/15/2020 18:13:51 Clomipramine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0