Drug Index

Dothiepin

 
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Mechanism :

Dothiepin hydrochloride is an antidepressant of the tricyclic family. The clinical effect is due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings. Also blocks uptake of serotonin.


Indication :

• Depression

• Bruxism


Contraindications :

Dothiepin is contraindicated in patients who have shown prior hypersensitivity to it and in acute porphyria, hepatic impairment and cardiovascular disease.


Dosing :

12-18 years: 50-75 mg at bedtime or in divided doses orally. Max dose: 150 mg/day.


Adverse Effect :

Mainly anticholinergic effects, sedation, postural hypotension, tremor, sweating, arrhythmia, increased appetite and weight gain, sexual dysfunction and lowered seizure threshold.


Interaction :

MAOIs: Hyperpyretic crises, severe convulsions, and deaths have occurred in patients receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously.
OCPs, Calcium Channel Blockers, Cimetidine, Phenothiazines, SSRIs: Plasma concentration of imipramine increased.
Rifampicin, Anti-Coagulants: Decreased plasma concentration of Imipramine.
Sedatives, Hypotensives, Drugs that Prolong QT Interval: Increased effects of these drugs.


07/15/2019 06:19:37 Dothiepin
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