Drug Index

Sertraline

 
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Mechanism :

It is an antidepressant agent used in the treatment of depression in children.


Indication :

• Management of major depressive disorder

• Posttraumatic stress disorder

• Obsessive-compulsive disorder

• Panic disorder with or without agoraphobia

• Premenstrual dysphoric disorder

• Social phobia

• Premature ejaculation

• Vascular headaches


Contraindications :

Hypersensitivity.

Do not use disulfiram concomitantly with oral solution due to alcohol in preparation

Concomitant pimozide: Risk of long QT syndrome.


Dosing :

>6 years: Initially 12.5-25 mg PO 24 hourly increasing slowly as required over several weeks till desired response is seen. Max: 200 mg/day.


Adverse Effect :

Diarrhoea, nausea, headache, insomnia, ejaculation disorder, dizziness, dry mouth, fatigue, somnolence, agitation, anorexia, constipation, dyspepsia and decreased libido.


Interaction :

Linezolid: May increase risk of serotonin syndrome, neuroleptic malignant syndrome.
Pimozide: May increase pimozide levels, risk of QT prolongation, cardiac arrhythmias.
Isocarboxazid: May increase risk of serotonin syndrome, neuroleptic malignant syndrome.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in normal renal function
HDNot dialysed. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Mild hepatic impairment: Decrease the dose to 50% of the normal daily dose.
Moderate to severe hepatic impairment: Avoid using sertaline.
05/24/2020 21:28:44 Sertraline
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