Drug Index

Fluvoxamine Maleate

 
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Mechanism :

Fluvoxamine is a specific serotonin reuptake inhibition in brain neurons. In fluvoxamine maleate had no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors.


Indication :

• Obsessive compulsive disorder

• Depression


Contraindications :

Co-administration of thioridazine, terfenadine, astemizole, cisapride, pimozide, alosetron or tizanidine with fluvoxamine maleate is contraindicated. Fluvoxamine maleate tablets are contraindicated in patients with a history of hypersensitivity to fluvoxamine maleate.


Dosing :

Obsessive Compulsive Disorder:

Under 8 years: Safety and efficacy not established.

8 to 17 years:

Initial immediate release dose: 25 mg orally once a day at bedtime.

Maintenance dose: 25 to 100 mg orally twice a day. The dose may be increased in 25 mg increments every 4 to 7 days, as tolerated, up to a maximum dose of 200 mg per day in children 8-11 years and upto 300 mg in children between 11-17 years.


Adverse Effect :

Nausea, headache, light headedness, restlessness, anxiety, weight loss, seizures, rash, urticaria, fever, neuroleptic malignant syndrome, social disinhibition, euphoria, precipitation of mania, diminished libido, anorgasmia, xerostomia, abnormal ejaculation.


Interaction :

Lithium: There have been reports of both increased and decreased lithium levels.
Benzodiazepines: half-life of concurrently administered diazepam may be prolonged in some patients. Coadministration of alprazolam and fluvoxamine has resulted in increased alprazolam plasma concentrations.
Haloperidol and Clozapine: Elevation of blood levels of haloperidol and clozapine has been observed in patients receiving concomitant fluvoxamine.
Carbamazepine: elevated plasma anticonvulsant concentrations and clinical anticonvulsant toxicity.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50Dose as in normal renal function
10-30Dose as in normal renal function
<10Dose as in normal renal function but titrate slowly

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxNot dialysed. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Because fluvoxamine is significantly metabolized in the liver, a lower initial dose and a slower increase in dose are advisable.
05/22/2020 15:46:43 Fluvoxamine Maleate
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