Drug Index

Cefaclor

 
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Mechanism :

Cefaclor is a semisynthetic second-generation cephalosporin antibiotic for oral administration. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.


Indication :

• Tonsillitis

• Rhinosinusitis

• Otitis media

• External otitis

• Epiglottitis

• Impetigo

• Pyoderma

• Gonococcal infection

• Pyelonephritis

• Cystitis


Contraindications :

Cefaclor is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.


Dosing :

Oral: 20 mg/kg/day in 3 divided doses. In serious infections, dose can be doubled.


Adverse Effect :

Serum-sickness-like reactions; erythema multiforme, rashes, arthritis/arthralgia, with or without fever. Other side effects observed are diarrhea, nausea and vomiting, transient hepatitis and cholestatic jaundice, transient lymphocytosis, leukopenia, hemolytic anemia, reversible neutropenia, hyperactivity, insomnia, dizziness, hallucinations.


Interaction :

Probenecid: Prolongs serum penicillin levels by slowing the rate of excretion by competitively inhibiting renal tubular secretion.
Warfarin: Prolongation of prothrombin time.


07/19/2019 03:39:38 Cefaclor
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