Drug Index


Mechanism :

Cefaclor is a semisynthetic second-generation cephalosporin antibiotic for oral administration. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.

Indication :

  • Tonsillitis
  • Rhinosinusitis
  • Otitis media
  • External otitis
  • Epiglottitis
  • Impetigo
  • Pyoderma
  • Gonococcal infection
  • Pyelonephritis
  • Cystitis

Contraindications :

Cefaclor is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Dosing :

20 mg/kg/day in 3 divided doses. In serious infections, dose can be doubled.

Adverse Effect :

Serum-sickness-like reactions; erythema multiforme, rashes, arthritis/arthralgia, with or without fever. Other side effects observed are diarrhea, nausea and vomiting, transient hepatitis and cholestatic jaundice, transient lymphocytosis, leukopenia, hemolytic anemia, reversible neutropenia, hyperactivity, insomnia, dizziness, hallucinations.

Interaction :

Probenecid: Prolongs serum penicillin levels by slowing the rate of excretion by competitively inhibiting renal tubular secretion.
Warfarin: Prolongation of prothrombin time.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10250 mg every 8 hours

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. 250 mg every 8–12 hours
HDDialysed. 250–500 mg every 8 hours
HDF/High fluxDialysed. 250–500 mg every 8 hours
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
03/23/2024 05:39:34 Cefaclor
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