Drug Index


Mechanism :

The bactericidal action of ceftizoxime results from inhibition of cell-wall synthesis. Cefizox is highly resistant to a broad spectrum of beta-lactamases. It is active against Klebsiella; Proteus mirabilis; Escherichia coli; Haemophilus influenzae including ampicillin-resistant strains; Staphylococcus aureus (penicillinase- and non-penicillinase-producing); Serratia spp.; Enterobacter spp.; Bacteroides spp.; and Streptococcus spp. including S. pneumoniae.

Indication :

  • Lower respiratory tract infections
  • Urinary tract infections
  • Intra-abdominal infections
  • Septicemia
  • Skin and soft tissue infections
  • Bone and joint infections

Contraindications :

Documented hypersensitivity.

Dosing :

Neonates (off-label):
25-50 mg/kg IV every 12 hours.
<6 months old (off-label):
100-200 mg/kg/day IV divided every 8 hourly.
>6 months old:
150-200 mg/kg/day IV divided every 6-8 hourly; maximum dose: 12 g/day.

Adverse Effect :

Fever, pruritus, skin rash, leukopenia, thrombocytopenia, rise in liver enzymes and blood urea.

Interaction :

Live vaccines: Decrease the effect of the vaccines by pharmacodynamic synergism.

Hepatic Dose :

No dosage adjustments are recommended.
03/21/2024 01:16:30 Ceftizoxime
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