Drug Index


Mechanism :

Cyclizine is a piperazine derivative with histamine H1-receptor antagonist (antihistamine) activity. The precise mechanism of action in inhibiting the symptoms of motion sickness is not well understood. It may have effects directly on the labyrinthine apparatus and on the chemoreceptor trigger zone. Cyclizine exerts a central anticholinergic (antimuscarinic) action.

Indication :

  • Vomiting
  • Motion sickness
  • Meniere disease
  • Vestibular vertigo

Contraindications :

Cyclizine should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal tract and hepatic disease. Dose reduction may be necessary in renal impairment, in epilepsy and severe heart failure. Cyclizine injection may have a hypertensive effect.

Dosing :

6-12 years:
Oral 25 mg/dose upto 3 times a day, maximum dose: 75 mg/day.
>12 years:
50 mg oral upto 4 times a day 30 min before travel, maximum 200 mg/24 hours.

Adverse Effect :

Drowsiness, occasional dry mouth, blurred vision, headache, psychomotor impairment, anti-muscarinic effects such as urinary retention and gastrointestinal disturbance, urticaria, drug rash, tachycardia, restlessness, nervousness, insomnia and hallucinations.

Interaction :

CNS Depressants: There may be additive effects with the co-administration.
Anticholinergic drugs: Side-effects enhanced.
Tricyclics, Antimuscarinics, Anxiolytics and Hypnotics: Increased antimuscarinic and sedative effects.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in normal renal function
HDUnknown dialysability. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Use with caution as cyclizine undergoes hepatic metabolism. Avoid in severe hepatic impairment.
01/19/2024 06:50:47 Cyclizine
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