Drug Index

Mantoux PPD

Synonyms :

PPD, Tuberculin PPD, Tuberculin-Purified Protein Derivative

Mechanism :

Tuberculin Purified Protein Derivative is indicated for the detection of a delayed hypersensitivity reaction to tuberculin as an aid in the detection of infection with Mycobacterium tuberculosis.

Indication :

  • Diagnosis of latent TB infection

Contraindications :

Allergy to any component of Tuberculin Purified Protein Derivative or an allergic reaction to a previous test, are contraindications to the use of tuberculin. It should not be administered to persons who previously experienced a severe reaction (e.g. vesiculation, ulceration or necrosis) because of the severity of reactions that may occur at the test site.

Dosing :

1-2 TU of 23 RT PPD 0.1 ml intradermal on left forearm. Result is read 48-72 hours after administration.

Adverse Effect :

Exaggerated reactions such as ulceration and regional lymphadenopathy can rarely occur Lymphangitis and anaphylaxis are very rare. Bleeding at the injection site (occurring up to 3 days after the skin test), rash, vesiculation, ulceration, itching, pain, redness, or swelling at the injection site.

Interaction :

Reactivity to the test may be depressed or suppressed for up to 6 weeks in individuals who are receiving corticosteroids or immunosuppressive agents. Reactivity to PPD may be temporarily depressed by certain live virus vaccines (measles, mumps, rubella, oral polio, yellow fever, and varicella). Therefore, if a tuberculin test is to be performed, it should be administered either before or simultaneously, at separate sites, with these vaccines in combined form or as separate antigens, or testing should be postponed for 4-6 weeks.

Hepatic Dose :

No dosage adjustments are recommended.
03/24/2024 11:16:30 Mantoux PPD
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