Drug Index

Pyrazinamide

 
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Mechanism :

Pyrazinamide, the pyrazine analogue of nicotinamide, is an antituberculosis agent. Pyrazinamide may be bacteriostatic or bactericidal against Mycobacterium tuberculosis depending on the concentration of the drug attained at the site of infection. The mechanism of action is unknown. In vitro and in vivo the drug is active only at a slightly acidic pH.


Indication :

• Tuberculosis


Contraindications :

Contraindicated in known hypersensitivity, in severe hepatic damage, and acute gout. Monitor liver function before and during treatment. Baseline and regular monitoring of liver function is required in patients with known chronic liver disease and in those known to be hepatitis B or C antigen positive.


Dosing :

30-35 mg/kg/24 hours as single dose or in 2 divided doses PO (Max: 2 gm/day) for the first 2 months of the standard 6 month regimen.


Adverse Effect :

Hepatic cell function, fever, anorexia, malaise, liver tenderness, hepatomegaly and splenomegaly, active gout, sideroblastic anemia, arthralgias, anorexia, nausea and vomiting, dysuria, malaise, fever, urticaria, aggravation of peptic ulcer.


Interaction :

Probenecid and Sulfinpyrazone: Antagonises the effect of probenecid and sulfinpyrazone.


07/21/2019 21:45:41 Pyrazinamide
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