Drug Index

Valganciclovir

 
print

Mechanism :

Valganciclovir is an L-valyl ester (prodrug) of ganciclovir that exists as a mixture of two diastereomers. After oral administration, both diastereomers are rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is a synthetic analogue of deoxyguanosine, which inhibits replication of human cytomegalovirus in vitro and in vivo.


Indication :

• Cytomegalovirus (CMV) retinitis in patients with AIDS

• Prevention of cytomegalovirus (CMV) disease in kidney, heart, and kidney-pancreas transplant patients at high risk

• Congenital CMV


Contraindications :

Contraindicated in patients with hypersensitivity to valganciclovir or ganciclovir.


Dosing :

Oral

For patients with active CMV retinitis for adolescents:

Induction: 900 mg twice daily for 21 days.

Maintenance: Following induction treatment or for patients with inactive CMV retinitis who require maintenance therapy: 900 mg once daily.

For the Prevention of CMV Disease in Heart, Kidney, and Kidney-Pancreas:

Transplantation: For patients who have received a kidney, heart, or kidney-pancreas transplant, the recommended dose is 250 mg/m² once daily with food starting within 10 days of transplantation until 100 days post transplantation.

Congenital CMV:

15 mg/kg/dose twice a day for 6 months.


Adverse Effect :

Leukopenia, thrombocytopenia, anemia, rash, abnormal LFTs, chills, edema, confusion ataxia, nervousness, paresthesia, psychosis, tremor, hypotension, hypertension, cardiac arrhythmias, gastrointestinal effects including abdominal pain, diarrhea, nausea, haemorrhage, eosinophilia, decreased blood glucose, fever, headache, insomnia, retinal detachment, alopecia, pruritus, urticaria, haematuria, increases in serum creatinine and urea also reported.


Interaction :

Zidovudine: Since both zidovudine and ganciclovir have the potential to cause neutropenia and anemia, some patients may not tolerate concomitant therapy with these drugs at full dosage.
Probenecid: Renal clearance of ganciclovir decreased which is consistent with an interaction involving competition for renal tubular secretion.
Imipenem-Cilastatin: Generalized seizures have been reported in patients who received ganciclovir and imipenem-cilastatin. These drugs should not be used concomitantly unless the potential benefits outweigh the risks.
Dapsone, Pentamidine, Flucytosine, Vincristine, Vinblastine, Adriamycin, Amphotericin B, Trimethoprim/Sulfamethoxazole combinations or other Nucleoside Analogues: Drugs that inhibit replication of rapidly dividing cell populations such as bone marrow, spermatogonia and germinal layers of skin and gastrointestinal mucosa may have additive toxicity when administered concomitantly with ganciclovir. Therefore, such drugs, should be considered for concomitant use with ganciclovir only if the potential benefits are judged to outweigh the risks involved.


07/17/2019 20:45:16 Valganciclovir
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0