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Posted On : 17 Aug 2025

Valparin, gardinal, eptoin, tegretal, these are four common drugs used in seizures. Which of the combinations have synergistic action and can be used together, and which drugs should not be used together?

Expert Answer :

Answer Discussion :

A

Abdalla Almatbagi

0

Valporate+ Tegritol

4 Days ago

N

Najat Ab

0

valperoate and tegretal

5 Days ago

?

?????????? ?????

0

valpoate +Tegeretol is better ...

5 Days ago

D

Dfsa Ata

0

synergestic effect valparin and eptoin ,
eptoin and tegretal also have a synergestic effect.

drugs should not use together are the valprain and tegretal

5 Days ago

D

Dr Trupti Bhosale

1

valproate and phenobarbital have synergistic action .
drugs can be used together are
valproate + phenobarbital
valproate+ carbamazepine with monitoring

should be avoided are valproate + phenytoin, carbamazepine + phenytoin and carbamazepine + phenobarbital

6 Days ago

Answer 1

Tegretol and Gardinal, when taken together, can cause increased levels of Gardinal, similar to the interaction with Eptoin and Tegretol. Valparin is ok to use with any of the other three and is synergistic with Tegretol. Do not use Tegretol for a generalized seizure like absence epilepsy, as it can severely worsen the epilepsy. Additive side effects need to be monitored with eptoin and valparin, both lowering platelet count, the first three causing liver side effects.

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