Drug Index

Mechanism :

The precise mechanism by which oxcarbazepine and MHD exert their antiseizure effect is unknown; however, in vitro electrophysiological studies indicate that they produce blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neural membranes, inhibition of repetitive neuronal firing, and diminution of propagation of synaptic impulses.

Indication :

  • Partial seizures with or without secondary GTCS- as adjunctive treatment or monotherapy.

Contraindications :

Should not be used in patients with a known hypersensitivity to oxcarbazepine or to any of its components. Caution In liver and renal disease, hyponatremia, heart failure and cardiac conduction disorders. Avoid abrupt withdrawal.

Dosing :

8-10 mg/kg/day in 2 divided doses. May titrate to higher doses. Max: 600 mg/day.

Adverse Effect :

Dizziness, headache, ataxia, somnolence, abnormal gait, tremors, vertigo, diplopia, abnormal vision, nystagmus, nausea, vomiting, abdominal pain.

Interaction :

Phenobarbital and Phenytoin: May increase plasma levels.
Carbamazepine: May decrease levels.
Oral Contraceptives: May reduce effect of oral contraceptives.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50Dose as in normal renal function
10-30Dose as in normal renal function. Start with 300 mg daily and titrate slowly
<10Dose as in normal renal function. Start with 300 mg daily and titrate slowly

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in GFR<10 mL/min
HDUnknown dialysability. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in GFR=10–30 mL/min

Hepatic Dose :

Mild to moderate hepatic impairment: No dosage adjustments are recommended.
Severe hepatic impairment: Use with caution immediate release preparation. Extended release preparations should be avoided.
09/26/2020 21:48:58 Oxcarbazepine
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