Drug Index

Oxcarbazepine

 
print

Mechanism :

The precise mechanism by which oxcarbazepine and MHD exert their antiseizure effect is unknown; however, in vitro electrophysiological studies indicate that they produce blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neural membranes, inhibition of repetitive neuronal firing, and diminution of propagation of synaptic impulses.


Indication :

• Partial seizures with or without secondary GTCS- as adjunctive treatment or monotherapy.


Contraindications :

Should not be used in patients with a known hypersensitivity to oxcarbazepine or to any of its components. Caution In liver and renal disease, hyponatremia, heart failure and cardiac conduction disorders. Avoid abrupt withdrawal.


Dosing :

Oral: 8-10 mg/kg/day in 2 divided doses. May titrate to higher doses. Max: 600 mg/day.


Adverse Effect :

Dizziness, headache, ataxia, somnolence, abnormal gait, tremors, vertigo, diplopia, abnormal vision, nystagmus, nausea, vomiting, abdominal pain.


Interaction :

Phenobarbital and Phenytoin: May increase plasma levels.
Carbamazepine: May decrease levels.
Oral Contraceptives: May reduce effect of oral contraceptives.


07/18/2019 09:48:46 Oxcarbazepine
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0