Drug Index



Mechanism :

Precise mechanism of action unknown but is a GABA analogue that binds to a subunit of voltage-gated calcium channels in CNS; does not affect sodium channels, opiate receptors, or cyclo-oxygenase enzyme activity; interactions with descending noradrenergic and serotonergic pathways originating from the brain stem appear to reduce neuropathic pain transmission from spinal cord.

Indication :

• Neuropathic pain (diabetic, spinal cord injury associated)

• Post-herpetic neuralgia

• Adjunctive therapy in partial seizures

• Fibromyalgia

Contraindications :

Avoid abrupt withdrawal.

Dosing :

Partial Onset Seizures:

1 month to 16 years:

< 29 kg: 3.5 mg/kg/day PO given in 2 or 3 divided doses; may increase the dosage weekly up to 14 mg/kg/day.

>30 kg: 2.5 mg/kg/day PO given in 2 or 3 divided doses; may increase the dosage weekly up to 10 mg/kg/day. Max: 600 mg/day.

Adverse Effect :

Hypersensitivity reaction, anaphylactoid reaction, angioedema, exfoliative dermatitis, Stevens-Johnson syndrome, thrombocytopenia, rhabdomyolysis, withdrawal seizures if abruptly discontinued.

Interaction :

Interaction Characteristics:
CNS depression.
Avoid/Use Alternative:
Doxylamine, Ginkgo.

03/15/2020 17:07:08 Pregabalin
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0