Drug Index



Mechanism :

Clobazam is a benzodiazepine derivative. It is an anxiolytic and an anticonvulsant.

Indication :

• Absence seizure

• Tonic and clonic seizure

• Atonic seizure

• Myoclonic seizure

• Partial seizure

• Catamenial (menstruation) seizures

• Cluster seizure

Contraindications :

Acute severe respiratory insufficiency, alcohol or drug dependence, myasthenia gravis, sleep apnea, hepatic dysfunction. Dose adjustment is required in hepatic and renal impairment.

Dosing :

<12 years: Initially oral 125 microgram/kg/dose BDS, followed by 250 microgram/dose, Max: 500 microgram/dose in 2 doses.

12-18 years: 10 mg/dose 2 times daily followed by maintenance doses 10-15 mg/dose, Max: 30 mg/dose in 2 doses.

Adverse Effect :

Somnolence, pyrexia, tachyphylaxis, behaviour disturbance and cognitive dysfunction.

Interaction :

Antiepileptics: May alter plasma levels of other antiepileptics.
Cimetidine: May enhance the effects.
Rifampicin: May reduce the effects of clobazam.

03/13/2020 19:42:40 Clobazam
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