Pentobarbital Sodium
Mechanism :
It is a shorter acting barbiturate used as a sedative or a hypnotic.
Indication :
- Sedation
- Status Epilepticus
Contraindications :
Hypersensitivity, Liver function impairment, Latent porphyria, Chronic or acute pain.
Dosing :
2-6 mg/kg/day PO, PR, IM in 3 divided doses or as slow IV. Maximum dose: 100 mg.
Adverse Effect :
Hypotension (associated with rapid administration), hypothermia, oliguria, cardiac arrhythmias, respiratory depression, CNS depression/excitation and vomiting. It is contraindicated in patients with porphyria.
Interaction :
Barbiturates: Enzyme inducers decrease effect of concomitantly administered drugs
Hepatic Dose :
Dose adjustment guidelines are not available. Dose reduction is recommended. Use with caution and drug should not be used in patients who have hepatic encephalopathy.