Drug Index

Clobazam

 
print

Mechanism :

Clobazam is a benzodiazepine derivative. It is an anxiolytic and an anticonvulsant.


Indication :

• Absence seizure

• Tonic and clonic seizure

• Atonic seizure

• Myoclonic seizure

• Partial seizure

• Catamenial (menstruation) seizures

• Cluster seizure


Contraindications :

Acute severe respiratory insufficiency, alcohol or drug dependence, myasthenia gravis, sleep apnea, hepatic dysfunction. Dose adjustment is required in hepatic and renal impairment.


Dosing :

<12 years: Initially oral 125 microgram/kg/dose BDS, followed by 250 microgram/dose, Max: 500 microgram/dose in 2 doses.

12-18 years: 10 mg/dose 2 times daily followed by maintenance doses 10-15 mg/dose, Max: 30 mg/dose in 2 doses.


Adverse Effect :

Somnolence, pyrexia, tachyphylaxis, behaviour disturbance and cognitive dysfunction.


Interaction :

Antiepileptics: May alter plasma levels of other antiepileptics.
Cimetidine: May enhance the effects.
Rifampicin: May reduce the effects of clobazam.


07/14/2019 19:49:40 Clobazam
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0