Drug Index

Clobazam

Mechanism :

Clobazam is a benzodiazepine derivative. It is an anxiolytic and an anticonvulsant.


Indication :

  • Absence seizure
  • Tonic and clonic seizure
  • Atonic seizure
  • Myoclonic seizure
  • Partial seizure
  • Catamenial (menstruation) seizures
  • Cluster seizure

Contraindications :

Acute severe respiratory insufficiency, alcohol or drug dependence, myasthenia gravis, sleep apnea, hepatic dysfunction. Dose adjustment is required in hepatic and renal impairment.


Dosing :

<12 years:
Initially oral 125 microgram/kg/dose BDS, followed by 250 microgram/dose, Max: 500 microgram/dose in 2 doses.
12-18 years:
10 mg/dose 2 times daily followed by maintenance doses 10-15 mg/dose, Max: 30 mg/dose in 2 doses.

Adverse Effect :

Somnolence, pyrexia, tachyphylaxis, behaviour disturbance and cognitive dysfunction.


Interaction :

Antiepileptics: May alter plasma levels of other antiepileptics.
Cimetidine: May enhance the effects.
Rifampicin: May reduce the effects of clobazam.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function. Start with low doses

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnlikely to be dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnlikely to be dialysed. Dose as in GFR<10 mL/min
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Mild to moderate hepatic impairment
> 30 kg: Start with 5 mg PO OD and increase to 5 mg PO BD after one week, 10 mg PO BD after 2 weeks and then 20 mg PO BD at the end of 3 weeks if clinically indicated.
< 30kg: Start with 5 mg PO OD and increase to 5 mg PO BD after two weeks, 10 mg PO BD after 3 weeks if clinically indicated.
Severe hepatic impairment
Dosing data not available.
08/09/2024 22:37:39 Clobazam
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0