Drug Index

Alprazolam

 
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Mechanism :

Alprazolam is a benzodiazepine. Benzodiazepines presumably exert their effects by binding at stereo specific receptors at several sites within the central nervous system at the GABA receptor complex. All benzodiazepines cause a dose-related central nervous system depressant activity.


Indication :

• Anxiety disorder

• Panic disorder

• Sedative


Contraindications :

Respiratory depression, especially seen with coexistent respiratory disease or myasthenia gravis.

There is potential for growing dependence, therefore only short-term use is recommended.

Acute porphyria.

Narrow-angle glaucoma.


Dosing :

Safety and efficacy of its use in children <18 years of age has not been established.

Anxiety:

≥7 years-18 years: 0.005 to 0.02 mg/kg/dose 3 times PO daily. Max: 3.5 mg/day.

Discontinuation of therapy

Abrupt discontinuation should be avoided. Daily dose must be gradually decreased no more frequently than every 3 days.


Adverse Effect :

Occurs are onset of therapy: drowsiness, ataxia, irritability, light-headedness, dysarthria and disinhibition. Withdrawal symptoms on long term usage: muscle cramps, tremor, irritability, convulsions and perceptual distortions.


Interaction :

CNS depressants: Enhanced effectiveness.
Fluoxetine: Coadministration with alprazolam increases the maximum plasma concentration of alprazolam.
Propoxyphene: Coadministration decreases the maximum plasma concentration of alprazolam.
Oral Contraceptives: Coadministration increases the maximum plasma concentration of alprazolam.
Antifungal Agents (Azole Derivatives, Systemic): May decrease the metabolism of Benzodiazepines (metabolized by oxidation).
Carbamazepine: May increase the metabolism of Benzodiazepines (metabolized by oxidation).
Cimetidine: May decrease the metabolism of Benzodiazepines (metabolized by oxidation).


08/06/2019 12:14:32 Alprazolam
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