Buspirone
Mechanism :
Buspirone is an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.
Indication :
- Anxiety
- Hyperkinetic disorder
Contraindications :
Buspirone is contraindicated in patients hypersensitive to buspirone hydrochloride, in hepatic and renal impairment and epilepsy.
Dosing :
Pre-adolescent:
2.5-5 mg every day oral, may increase every 3-4 days by 2.5 mg. Max dose: 20 mg/day.
Adolescent:
5-10 mg orally, every day. May increase weekly by 5 mg as needed. Max dose: 60 mg in 2-3 divided doses.
Adverse Effect :
Dizziness, drowsiness, nausea, headache, nervousness, light headedness, and excitement.
Interaction :
Warfarin: Prolonged prothrombin time.
Haloperidol: Increased serum haloperidol concentrations.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
20-50 | Dose as in normal renal function |
10-20 | Dose as in normal renal function |
<10 | Reduce by 25–50% if patient is anuric |
Dose in Patients undergoing Renal Replacement Therapies
CAPD | Not dialysed. Dose as in GFR<10 mL/min |
HD | Not dialysed. Dose as in GFR<10 mL/min |
HDF/High flux | Unknown dialysability. Dose as in GFR<10 mL/min |
CAV/VVHD | Not dialysed. Dose as in normal renal function |
Hepatic Dose :
Mild to moderate hepatic impairment: Start with low dose and adjust the dose based on clinical response.
Severe hepatic impairment: Avoid use in patients with severe hepatic dysfunction.