Drug Index

Buspirone

 
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Mechanism :

Buspirone is an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.


Indication :

• Anxiety

• Hyperkinetic disorder


Contraindications :

Buspirone is contraindicated in patients hypersensitive to buspirone hydrochloride, in hepatic and renal impairment and epilepsy.


Dosing :

Pre-adolescent: 2.5-5 mg every day oral, may increase every 3-4 days by 2.5 mg. Max dose: 20 mg/day.

Adolescent: 5-10 mg orally, every day. May increase weekly by 5 mg as needed. Max dose: 60 mg in 2-3 divided doses.


Adverse Effect :

Dizziness, drowsiness, nausea, headache, nervousness, light headedness, and excitement.


Interaction :

Warfarin: Prolonged prothrombin time.
Haloperidol: Increased serum haloperidol concentrations.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Reduce by 25–50% if patient is anuric

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDNot dialysed. Dose as in normal renal function

Hepatic Dose :

Mild to moderate hepatic impairment: Start with low dose and adjust the dose based on clinical response.
Severe hepatic impairment: Avoid use in patients with severe hepatic dysfunction.
04/12/2020 17:57:35 Buspirone
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