Cefuroxime
Mechanism :
Cefuroxime is a semisynthetic, broad-spectrum, second generation cephalosporin antibiotic for parenteral administration.
Indication :
- Pharyngitis/Tonsillitis
- Pneumonia
- Sinusitis
- Otitis media
- Skin and soft tissue infections
- Gonorrhoea
- Osteomyelitis
- Lyme disease
Contraindications :
Cefuroxime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Dosing :
<3 months:
Safety and efficacy not established.
>3 months-12 years:
30 mg/kg/day in 12 hourly divided doses for 10 days (Maximum: 1 g/day). Alternatively, 75-150 mg/kg/day IV/IM in 8 hourly divided doses for severe infections; do not exceed 6 g/day. Duration varies with infection type.
>12 years:
250-500 mg tablet every 12 hours for 10 days.
Neonates (off-label):
<7 days, <2 kg: 100 mg/kg/day divided 12 hourly IV.
<7 days, >2 kg: 150 mg/kg IV/IM divided 8 hourly.
>7 days: 150 mg/kg IV/IM divided 8 hourly.
Adverse Effect :
Pseudomembranous colitis, nausea and vomiting, diarrhea, rash, urticaria, angioedema, pruritus, false positive urine glucose test, positive direct Coombs tests.
Interaction :
Argatroban: Increases the level of argatroban by anticoagulation.
Bivalirudin: Increases the level of bivalirudin by anticoagulation.
Fondaparinux: Increases the level of fondaparinux by anticoagulation.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
| 20-50 | Dose as in normal renal function |
| 10-20 | Dose as in normal renal function |
| <10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
| CAPD | Dialysed. Dose as in normal renal function |
| HD | Dialysed. Dose as in normal renal function |
| HDF/High flux | Dialysed. Dose as in normal renal function |
| CAV/VVHD | Dialysed. Dose as in normal renal function |
Hepatic Dose :
No dosage adjustments are recommended.