Drug Index


Mechanism :

Cefuroxime is a semisynthetic, broad-spectrum, second generation cephalosporin antibiotic for parenteral administration.

Indication :

  • Pharyngitis/Tonsillitis
  • Pneumonia
  • Sinusitis
  • Otitis media
  • Skin and soft tissue infections
  • Gonorrhoea
  • Osteomyelitis
  • Lyme disease

Contraindications :

Cefuroxime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Dosing :

<3 months:
Safety and efficacy not established.
>3 months-12 years:
30 mg/kg/day in 12 hourly divided doses for 10 days (Maximum: 1 g/day). Alternatively, 75-150 mg/kg/day IV/IM in 8 hourly divided doses for severe infections; do not exceed 6 g/day. Duration varies with infection type.
>12 years:
250-500 mg tablet every 12 hours for 10 days.
Neonates (off-label):
<7 days, <2 kg: 100 mg/kg/day divided 12 hourly IV.
<7 days, >2 kg: 150 mg/kg IV/IM divided 8 hourly.
>7 days: 150 mg/kg IV/IM divided 8 hourly.

Adverse Effect :

Pseudomembranous colitis, nausea and vomiting, diarrhea, rash, urticaria, angioedema, pruritus, false positive urine glucose test, positive direct Coombs tests.

Interaction :

Argatroban: Increases the level of argatroban by anticoagulation.
Bivalirudin: Increases the level of bivalirudin by anticoagulation.
Fondaparinux: Increases the level of fondaparinux by anticoagulation.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDDialysed. Dose as in normal renal function
HDDialysed. Dose as in normal renal function
HDF/High fluxDialysed. Dose as in normal renal function
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
10/21/2023 18:00:18 Cefuroxime
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