Drug Index

Meclizine

 
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Mechanism :

It is an anti-histaminic drug used as an anti-emetic. It has lesser antimuscarinic and lesser sedating properties. It is used to prevent and treat nausea and vomiting associated with motion sickness, Meniere’s disease, sea sickness, vertigo and chronic labyrinthitis.


Indication :

• Nausea/vomiting

• Vertigo

• Motion Sickness


Contraindications :

Renal impairment, Hepatic impairment, IOP increased, Glaucoma, COPD asthma, PUD, Hyperthyroidism, Hypertension, Lower resp. tract SX, GI obstruction, Prostatic hypertrophy, Bladder neck obstruction, High environmental temperature.


Dosing :

>12 years: 25 mg orally 1 to 4 times a day or 50 mg orally twice a day. Meclizine should be administered one hour prior to travel and continued for the duration of exposure.


Adverse Effect :

Dry mouth, thickened bronchial secretions, constipation, GI upset, urinary retention, drowsiness, Rare: anaphylaxis/anaphylactoid reaction, hemolytic anemia, thrombocytopenia, agranulocytosis, pancytopenia, leukopenia, arrhythmias, seizures, blurred vision, diplopia, tachycardia, photosensitivity, palpitations, diaphoresis, rash, difficulty swallowing, hives.


Interaction :

AVOID:

Cinacalcet; Quinidine; Terbinafine; the Antidepressants Bupropion, Duloxetine, Fluoxetine, Paroxetine, or Sertraline.


07/14/2019 07:31:56 Meclizine
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