Drug Index

Cyanocobalamin

Synonyms :

Hydroxocobalamin, Mecobalamin, Vit B12, Vitamin B12

Mechanism :

The drug substance is the hydroxylated active form of vitamin B12 and is a large molecule in which a trivalent cobalt ion is coordinated in four positions by a tetrapyrrole ring.


Indication :

  • Vitamin B deficiency
  • Methylmalonic academia
  • Cobalamin utilization disorders
  • Homocystinuria-remethylation defects

Contraindications :

Do not give until diagnosis fully established and monitor plasma potassium during initial therapy.


Dosing :

RDA:
0-6 months:
0.4 mcg
7-12 months:
0.5 mcg
1-3 years:
0.9 mcg
4-8 years:
1.2 mcg
9-13 years:
1.8 mcg
>14 years:
2.4 mcg
Pernicious anaemia:
Start:
30-50 mcg SC/IM OD x14 days or give a total dose of 1000 mcg. Maintenance: 100 mcg IM/SC monthly.
Vitamin B12 deficiency:
IM/SC
0.2 mcg/kg for 2 days, followed by 1000 mcg/day for the next 2-7 days, this is then followed by 100 mcg/day for 2-7 days, then 100 mcg/week for 1 month. Maintenance dose: 100 mcg IM/SC monthly.

Adverse Effect :

Arthralgia, itching, chills, fever, hot flushes, headache, nausea, vomiting, dizziness and malaise.


Interaction :

No known interactions found.



Hepatic Dose :

No dosage adjustments are recommended.
05/27/2021 18:30:30 Cyanocobalamin
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