Drug Index


Synonym :

Vitamin B1

Mechanism :

Vitamin B1 is a water-soluble B complex vitamin. Vitamin B1 combines with adenosine triphosphate (ATP) to form thiamine pyrophosphate, also known as co carboxylase, a coenzyme. Its role in carbohydrate metabolism is the decarboxylation of pyruvic acid and alpha-ketoacids to acetaldehyde and carbon dioxide. Increased levels of pyruvic acid in the blood indicate vitamin B1 deficiency.

Indication :

  • Maple syrup urine disease (MSUD)-thiamine sensitive variants
  • Congenital lactic acidosis
  • Mitochondrial respiratory chain defects
  • Beri

Contraindications :

Hypersensitivity to vitamin B1 or any component of a product containing vitamin B1.

Dosing :

0-6 months: 0.2 mg daily.
6-12 months: 0.3 mg daily.
1-3 years: 0.5 mg daily.
3-8 years: 0.6 mg daily.
8-13 years: 0.9 mg daily.
13-18 years: 1.2 mg daily (Male); 1 mg daily (females).
Congenital lactic acidosis, MSUD:
Oral 100 mg once daily.
Usual Pediatric Dose for Beriberi:
10 to 25 mg IM or IV daily (if critically ill), or 10 to 50 mg orally every day for 2 weeks, then 5 to 10 mg orally daily for 1 month.

Adverse Effect :

Feeling of warmth, pruritus, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioneurotic edema, cyanosis, pulmonary edema, hemorrhage into the gastrointestinal tract, collapse and death have been rarely reported, mainly following repeated IV administration of the drug.

Interaction :

Potentially Fatal: May enhance the effect of neuromuscular blocking agents.

Hepatic Dose :

No dosage adjustments are recommended.
02/21/2024 23:39:51 Thiamine
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0