Drug Index

Tocopherol

 
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Synonyms :

Alpha Tocopherol, Vitamin E

Mechanism :

Vitamin E exhibit antioxidant activity. Vitamin E's anti-atherogenic activity involves the inhibition of the oxidation of low-density lipoprotein (oxLDL) and the accumulation of oxLDL in the arterial wall. It also appears to reduce oxLDL-induced apoptosis in human endothelial cells. Oxidation of LDL is a key early step in atherogenesis as it triggers a number of events which lead to the formation of atherosclerotic plaque.


Indication :

• Vitamin E Deficiency

• Neonatal cholestasis and chronic cholestasis

• Malabsorption syndrome

• Abetalipoproteinemia

• Cystic Fibrosis

• Dietary Supplement

• Prevention of retinopathy of prematurity or Bronchopulmonary dysplasia (BPD) secondary to oxygen therapy


Contraindications :

Pregnancy, Warfarin.


Dosing :

(1 unit vitamin E = 1 mg alpha-tocopherol acetate)

Cystic Fibrosis and cholestasis: Oral

Neonates, premature, low birth weight: 25-50 units/day.

1-12 months: 40-50 units daily.

1-3 years: 80-150 units daily. Max: 200 units/day.

4-8 years: 100 to 200 units daily. Max: 300 units/day.

>8 years: 200-400 units daily. Max: 600 units/day in 1-13 years and 800 units/day in 14-18 years).

Prevention of retinopathy of prematurity or Bronchopulmonary dysplasia (BPD) secondary to oxygen therapy:

15 to 30 units/kg/day to maintain plasma levels between 1.5 to 2 mcg/mL (May need as high as 100 units/kg/day).

Recommended Daily Allowance (RDA): Oral

1-6 months: 4 mg daily.

6-12 months: 5 mg daily.

1-3 years: 6 mg daily. Max: 200 mg/day.

4-8 years: 7 mg daily. Max: 300 mg/day.

9-13 years: 11 mg daily. Max: 600 mg/day.

13 years and older: 15 mg daily. Max: 800 mg/day.


Adverse Effect :

In some individuals who are vitamin K deficient, vitamin E may increase the risk for hemorrhage or bleeding. Vitamin E ointments, oils, or creams may trigger contact dermatitis. With doses >400 units a day and long-term use: blurred vision, diarrhea, flatulence, dizziness, headache, fatigue, nausea or stomach cramps, unusual tiredness or weakness, increased serum creatinine.


Interaction :

Warfarin (Coumadin): Interacts with VITAMIN E.
Niacin: Interacts with VITAMIN E.
Medications for cancer (Chemotherapy): Interacts with VITAMIN E.
Cyclosporine (Neoral, Sandimmune): Interacts with VITAMIN E.


08/10/2019 20:40:46 Tocopherol
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