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Ascorbic acid
Synonym :
Vitamin C
Mechanism :
Necessary for collagen formation and tissue repair in the body; involved in some oxidation-reduction as well as many other metabolic reactions.
Indication :
- Prevention and treatment of scurvy
- Increase iron excretion during deferoxamine administration
Contraindications :
Hypersensitivity to ascorbic acid or any component.
Dosing :
RDA:
0-6 months: 40 mg (~6 mg/kg/day)
6-12 months: 50 mg (~6 mg/kg/day)
1-3 years: 15 mg
3-8 years: 25 mg
8-13 years: 45 mg
13-18 years: Males-75 mg, Females-65 mg.
Scurvy:
100 mg (Oral) thrice daily for 1 week. Then 100 mg (Oral) everyday until condition resolves (1-3 months).
Adverse Effect :
Flushing, fainting, dizziness, headache, fatigue. nausea, vomiting, diarrhea, heartburn, diarrhea, hyperoxaluria. In thalassemia patients, it may increase the iron overload state.
Interaction :
Aspirin, iron, oral contraceptives (increases estrogen levels), decreases warfarin effect.
Renal Dose :
Dose in Renal Impairment GFR (mL/min)
20-50 | Dose as in normal renal function |
10-20 | Dose as in normal renal function |
<10 | Dose as in normal renal function |
Dose in Patients undergoing Renal Replacement Therapies
CAPD | Dialysed. Dose as in normal renal function |
HD | Dialysed. Dose as in normal renal function |
HDF/High flux | Dialysed. Dose as in normal renal function |
CAV/VVHD | Dialysed. Dose as in normal renal function |
Hepatic Dose :
No dosage adjustments are recommended.