ISSN - 0973-0958
   
 
Evaluation of Copper, Zinc and Copper-Zinc Ratio in the Serum of Pulmonary Tuberculosis Children
Boloursaz Mohammad Reza, Khalilzadeh Soheila, Milanifar Ali Reza, Hakimi seyed Shaheen, Khodayari Amir Ali, Velayati Ali Akbar.
Pediatric Pulmonary Ward, National Research Institute of Tuberculosis and Lung Disease, Shaheed Beheshti University of Medical Sciences, Iran.
 
Abstract

Tuberculosis is considered as one of the most important infectious diseases. It results in changes in the serum level of many micronutrients. Copper and Zinc are two important micronutrients in the immune system and metabolism. In this study the serum levels of Copper and zinc are evaluated in the children suffering from pulmonary tuberculosis. Also the effects of anti tuberculosis therapy on the serum levels of these micronutrients have been studied. This two phases (cross-sectional, cohort) study was conducted in National Research Institute of Tuberculosis and Lung Disease (NRITLD) during 2003-2004. A total of 45 children were divided into three groups: 1- Children suffering from pulmonary tuberculosis 2- Children with malnutrition 3- Healthy children, considered as control group. The serum levels of Copper and Zinc were measured before stating treatment was initiated. In children with tuberculosis serum Copper and Zinc levels were measured one and four months after therapy. Results demonstrated higher serum levels of Copper in children with tuberculosis as compared to the other two groups (P<0.05) and similar serum Zinc levels (P=0.5). Anti tuberculosis therapy results in a significant decrease in serum Copper levels. The zinc level in children with tuberculosis was significantly decreased and then increased during treatment. This study, in which the levels of Zinc and Copper have been studied in children suffering from pulmonary tuberculosis, is the first of such kind conducted in Iran.
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