Carbamide
Mechanism :
Carbamide peroxide, also called urea peroxide, is an oxidising agent, consisting of hydrogen peroxide compounded with urea.
Indication :
- Teeth whitening
- Canker sores or gum irritation
- Ear wax removal
Contraindications :
Hypersensitivity.
Dosing :
Use in children >2 years.
Canker sores or gum irritation:
Apply several drops to affected area, expectorate out after 2-3 minutes, OR
Place 10 drops on tongue, mix with saliva, swish in mouth for several minutes, then expectorate. May repeat up to 4 times/day.
Oral hygiene:
15% liquid: Apply to toothbrush, cover with toothpaste, brush & expectorate.
Ear wax removal: Available as otic 6.5% solution:
1 to 5 drops twice daily for up to 4 days (Max: 10 drops twice daily); individualize the dose according to patient size.
Adverse Effect :
The chemical is a skin, eye and respiratory irritant. It is also corrosive and causes burns. It doesn’t hurt at 10% concentration (3% peroxide equivalent) but it does hurt at 35% equivalent, causing white chemical burns on skin and gums alike.
Interaction :
With allogeneic cultured keratinocytes/fibroblasts in in bovine collagen: Decreases the effect of allogeneic cultured keratinocytes/fibroblasts in in bovine collagen.
Hepatic Dose :
No dosage adjustments are recommended.