Drug Index

Pentoxifylline

 
print

Mechanism :

It is a peripheral vasodilator used in the treatment of peripheral vascular disease (Raynaud’s disease).
It may be useful in lowering blood sugar level, also reduces blood pressure.


Indication :

• Intermittent claudication in certain patients to reduce pain, cramping, numbness, or weakness in the arms or legs.

• For patients with Kawasaki disease to reduce the incidence of coronary artery lesions


Contraindications :

Methylxanthine intolerance, Recent cerebral hemorrhage, Recent retinal hemorrhage.


Dosing :

Safety and efficacy have not been established in children.

Limited off-label data indicate 20 mg/kg/day PO in 3 divided doses.


Adverse Effect :

Arrhythmias, hypersensitivity reaction, dyspepsia, nausea.


Interaction :

Aspirin: Combining these medications may occasionally increase the risk of bleeding. Tamsulosin: Pentoxifylline may enhance the blood pressure lowering effects of tamsulosin. You may experience headache, dizziness, light-headedness, fainting, and/or changes in pulse or heart rate.



Renal Dose :

Dose in Renal Impairment GFR (mL/min)
30-50Dose as in normal renal function
10-30Reduce dose by 30–50% depending on individual tolerance (400 mg once or twice daily)
<10Reduce dose by 30–50% depending on individual tolerance (400 mg once or twice daily)

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. 400 mg daily, slowly increasing if necessary
HDNot dialysed. 400 mg daily, slowly increasing if necessary
HDF/High fluxUnknown dialysability. 400 mg daily, slowly increasing if necessary
CAV/VVHDNot dialysed. Dose as in GFR=10– 30 mL/min

Hepatic Dose :

No dose adjustment recommended.
07/29/2020 01:33:45 Pentoxifylline
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0