Drug Index

Papaverine

 
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Mechanism :

Smooth muscle spasmolytic producing a generalized smooth muscle relaxation including vasodilation, GI sphincter relaxation, bronchiolar muscle relaxation, and potentially a depressed myocardium.


Indication :

• For intravascular catheter occlusion prophylaxis


Contraindications :

Hypersensitivity to papaverine or any component .

Complete atrioventricular block, Parkinson’s disease.


Dosing :

Safety and efficacy not established in children.

Intra-Arterial dosage:

30 mg of papaverine added to 250 mL of arterial catheter infusion solution (0.9% or 0.45% NaCl with heparin 1 unit/mL) infused continuously at a rate of 1 mL/hour into a peripheral arterial catheter. Generally, avoid use in extremely premature neonates during the immediate period after birth when the risk of developing intracranial hemorrhage is highest.


Adverse Effect :

Tachycardia, BP changes, flushing, dizziness, drowsiness, depression, malaise, sweating, raised intracranial pressure, pruritus, rash, anorexia, diarrhea, constipation, dry mouth, nausea vomiting, priapism.


Interaction :

Serious - Use Alternative:

Sodium oxybate.


07/19/2019 03:03:12 Papaverine
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