Drug Index

Aztreonam

 
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Mechanism :

Originally isolated from Chromobacterium violaceum, it is a synthetic bactericidal antibiotic. Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa. The bactericidal action of aztreonam is due to the inhibition of bacterial cell wall synthesis.


Indication :

• Lower respiratory tract infections

• Urinary tract infection

• Septicemia

• Skin and soft tissue infections

• Intra-abdominal Infections


Contraindications :

This preparation is contraindicated in patients with known hypersensitivity to aztreonam or any other component in the formulation.


Dosing :

<9 months: Safety and Efficacy not established.

>9 months: IV: 30 mg/kg 6-8 hourly, maximum dose: 120 mg/kg/day.

Cystic Fibrosis:

>9 months: IV 50 mg/kg every 6-8 hours; maximum dose: 200 mg/kg/day; do not exceed 8 g/day.

>7 years: 75 mg thrice daily via nebulizer, at least 4 hours apart for 28 days; do not repeat for another 1 month.


Adverse Effect :

Hypersensitivity (anaphylaxis, angioedema, bronchospasm), pancytopenia, neutropenia, thrombocytopenia, anemia, eosinophilia, leucocytosis, thrombocytosis, abdominal cramps, pseudomembranous colitis, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, urticaria, petechiae, pruritus, diaphoresis, hypotension, transient ECG changes, wheezing, dyspnea, chest pain, hepatitis, jaundice, seizure, confusion, vertigo, paresthesia, insomnia, dizziness.


Interaction :

Avoid using antibiotics that induce beta-lactamase production (cefoxitin, imipenem); probenecid and furosemide increases aztreonam serum levels.


08/06/2019 12:35:25 Aztreonam
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