Drug Index



Mechanism :

Flumazenil is a benzodiazepine receptor antagonist. Flumazenil antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex.

Indication :

• Benzodiazepine overdose

Contraindications :

Contra-indicated in patients in patients with a known hypersensitivity to flumazenil or benzodiazepines, in patients who have been given a benzodiazepine for control of a life-threatening condition, and in patients who are showing signs of serious cyclic antidepressant overdose.

Dosing :

0.01 mg/kg given once intravenously over 15 seconds.

Adverse Effect :

Dizziness, increased sweating, headache, injection site pain, and abnormal or blurred vision. Others: cutaneous vasodilation, flushing, sweating, hot flushes, abnormal vision, diplopia, paresthesia, visual field defect, abnormal sensation, hypoesthesia, nausea, vomiting, headache, fatigue, agitation, nervousness, anxiety, tremor, palpitations, dry mouth, insomnia, dyspnea, dizziness, hyperventilation, emotional lability

Interaction :

Benzodiazepine: Flumazenil is not recommended in epileptic patients who have been receiving benzodiazepine treatment for a prolonged period.
Zopiclone, Triazolo Pyridazines and others: The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolo pyridazines and others, are also blocked by flumazenil.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10Dose as in normal renal function

Dose in Patients undergoing Renal Replacement Therapies
CAPDUnknown dialysability. Dose as in normal renal function
HDUnknown dialysability. Dose as in normal renal function
HDF/High fluxUnknown dialysability. Dose as in normal renal function
CAV/VVHDUnknown dialysability. Dose as in normal renal function

Hepatic Dose :

Since flumazenil is primarily metabolized in the liver, careful titration of dosage is recommended in patients with impaired hepatic function. Initial dose may not be adjusted. However, subsequent doses should be reduced in size or frequency.
06/22/2020 03:23:43 Flumazenil
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