Drug Index

Flumazenil

 
print

Mechanism :

Flumazenil is a benzodiazepine receptor antagonist. Flumazenil antagonizes the actions of benzodiazepines on the central nervous system. Flumazenil competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex.


Indication :

• Benzodiazepine overdose


Contraindications :

Contra-indicated in patients in patients with a known hypersensitivity to flumazenil or benzodiazepines, in patients who have been given a benzodiazepine for control of a life-threatening condition, and in patients who are showing signs of serious cyclic antidepressant overdose.


Dosing :

0.01 mg/kg given once intravenously over 15 seconds.


Adverse Effect :

Dizziness, increased sweating, headache, injection site pain, and abnormal or blurred vision. Others: cutaneous vasodilation, flushing, sweating, hot flushes, abnormal vision, diplopia, paresthesia, visual field defect, abnormal sensation, hypoesthesia, nausea, vomiting, headache, fatigue, agitation, nervousness, anxiety, tremor, palpitations, dry mouth, insomnia, dyspnea, dizziness, hyperventilation, emotional lability


Interaction :

Benzodiazepine: Flumazenil is not recommended in epileptic patients who have been receiving benzodiazepine treatment for a prolonged period.
Zopiclone, Triazolo Pyridazines and others: The effects of nonbenzodiazepine agonists at benzodiazepine receptors, such as zopiclone, triazolo pyridazines and others, are also blocked by flumazenil.


07/18/2019 11:52:59 Flumazenil
ask a doctor
Ask a Doctor
Disclaimer: The information given by www.pediatriconcall.com is provided by medical and paramedical & Health providers voluntarily for display & is meant only for informational purpose. The site does not guarantee the accuracy or authenticity of the information. Use of any information is solely at the user's own risk. The appearance of advertisement or product information in the various section in the website does not constitute an endorsement or approval by Pediatric Oncall of the quality or value of the said product or of claims made by its manufacturer.
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0