Drug Index

Carboplatin

 
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Mechanism :

Carboplatin is a platinum coordination compound that is used as a cancer chemotherapeutic agent. Carboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. This effect is apparently cell-cycle nonspecific.


Indication :

• Neuroblastoma stage IV

• Neuroectodermal tumors

• Medulloblastoma

• Rhabdomyosarcoma

• Sarcoma

• Germ cell tumor

• Glioma

• Astrocytoma

• Retinoblastoma

• Wilms Tumor

• Liver tumors


Contraindications :

Carboplatin is contraindicated in patients with a history of severe allergic reactions to cisplatin or other platinum-containing compounds, or mannitol. Carboplatin should not be employed in patients with severe bone marrow depression or significant bleeding.


Dosing :

Dosage varies according to the current treatment protocol. An increasing number of protocols determine doses based on glomerular filtration rate (GFR).

Children solid tumor: 300-600 mg/sq m IV once in 4 weeks.

Brain tumor: 175 mg/sq m IV once a week for 4 weeks.

Adolescent: 360 mg/sq m IV once in 4 weeks.


Adverse Effect :

Thrombocytopenia, leukopenia, anemia, neutropenia, nausea, vomiting, peripheral neuropathy, ototoxicity, neurotoxicity, elevated creatinine and blood urea, elevated bilirubin, alkaline phosphatase, SGOT.


Interaction :

Nephrotoxic drugs: Adverse effects increased.
Cidofovir: Combination may increase carboplatin levels, risk if toxicity; increase risk of myelosuppression.


07/17/2019 20:50:12 Carboplatin
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