Drug Index

Cefixime

 
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Mechanism :

Cefixime is a semisynthetic third generation cephalosporin antibiotic intended for oral administration. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.


Indication :

• Gram negative infections

• Urinary tract infections

• Diarrhea

• Enteric fever


Contraindications :

Cefixime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.


Dosing :

Children: Oral 8 mg/kg/24 hours in 1-2 divided doses;

In typhoid: 20 mg/kg/day in 2 divided doses for 14 days.

Adolescent: Oral 400 mg/24 hours in 1-2 divided doses.


Adverse Effect :

Pseudomembranous colitis, nausea and vomiting, diarrhea, hypersensitivity (rash, urticaria, angioedema, pruritus), hepatic dysfunction including cholestasis and elevations in serum transaminase, moderate transient neutropenia, fever, thrombocytopenia, erythema multiforme, Stevens-Johnson syndrome, serum sickness, and arthralgia.


Interaction :

False positive glycosuria reaction.
Cephalosporin: Positive direct Coombs tests have been reported during treatment with the cephalosporin antibiotics.


07/21/2019 21:45:34 Cefixime
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