Drug Index


Mechanism :

Cefixime is a semisynthetic third generation cephalosporin antibiotic intended for oral administration. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.

Indication :

  • Gram negative infections
  • Urinary tract infections
  • Diarrhea
  • Enteric fever

Contraindications :

Cefixime is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Dosing :

Oral 8 mg/kg/24 hours in 1-2 divided doses;
In typhoid:
20 mg/kg/day in 2 divided doses for 14 days.
Oral 400 mg/24 hours in 1-2 divided doses.

Adverse Effect :

Pseudomembranous colitis, nausea and vomiting, diarrhea, hypersensitivity (rash, urticaria, angioedema, pruritus), hepatic dysfunction including cholestasis and elevations in serum transaminase, moderate transient neutropenia, fever, thrombocytopenia, erythema multiforme, Stevens-Johnson syndrome, serum sickness, and arthralgia.

Interaction :

False positive glycosuria reaction.
Cephalosporin: Positive direct Coombs tests have been reported during treatment with the cephalosporin antibiotics.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10200 mg/day

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDNot dialysed. Dose as in GFR<10 mL/min
HDF/High fluxUnknown dialysability. Dose as in GFR<10 mL/min
CAV/VVHDDialysed. Dose as in GFR=10– 20 mL/min

Hepatic Dose :

No dosage adjustments are recommended.
02/21/2024 22:07:14 Cefixime
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