Drug Index


Mechanism :

Cefpodoxime proxetil is an orally administered extended spectrum, semi-synthetic antibiotic of the cephalosporin class. Cephalosporins are bactericidal because of their inhibition of cell-wall synthesis.

Indication :

  • Otitis media
  • Community acquired pneumonia
  • Tonsillitis
  • Pharyngitis
  • Enteric fever

Contraindications :

Cefpodoxime is contraindicated in patients with a known allergy to cefpodoxime or to the cephalosporin group of antibiotics.

Dosing :

<2 months:
Safety and efficacy not established.
2 months-12 years:
5 mg/kg (Oral) every 12 hours for 5-10 days;
maximum dose:
200 mg/dose.
>12 years:
200 mg (Oral) every 12 hours for 5-10 days.

Adverse Effect :

Colitis, diarrhea, nausea, vomiting, headache and allergic reactions.

Interaction :

Absorption is decreased by antacids and H2 antagonists.

Renal Dose :

Dose in Renal Impairment GFR (mL/min)
20-50Dose as in normal renal function
10-20Dose as in normal renal function
<10100–200 mg every 24 hours

Dose in Patients undergoing Renal Replacement Therapies
CAPDNot dialysed. Dose as in GFR<10 mL/min
HDDialysed. Dose as in GFR<10 mL/ min
HDF/High fluxDialysed. Dose as in GFR<10 mL/ min
CAV/VVHDDialysed. Dose as in normal renal function

Hepatic Dose :

No dosage adjustments are recommended.
02/16/2024 17:03:50 Cefpodoxime
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