Ceftibuten

Mechanism :

Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis.
Ceftibuten is stable in the presence of most plasmid-mediated beta-lactamases, but it is not stable in the presence of chromosomally-mediated cephalosporinases produced in organisms such as Bacteroides, Citrobacter, Enterobacter, Morganella, and Serratia. Like other beta-lactam agents, ceftibuten should not be used against strains resistant to beta-lactams due to general mechanisms such as permeability or penicillin-binding protein changes like penicillin-resistant S. pneumoniae.

Indication :

• Otitis Media
• Pharyngitis and Tonsillitis

Contraindications :

Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Dosing :

Adverse Effect :

Nausea, headache, diarrhea, dyspepsia, dizziness, abdominal pain, vomiting, anorexia, constipation, dry mouth, dyspnea, dysuria, eructation, fatigue, flatulence, paresthesia, pruritus, rash, somnolence, taste perversion, urticaria.

Interaction :

Theophylline: The pharmacokinetics of theophylline were not altered. The effect of ceftibuten on the pharmacokinetics of theophylline administered orally has not been investigated.
Drug/Laboratory Test Interactions: There have been no chemical or laboratory test interactions with ceftibuten noted to date. False-positive direct Coombs tests have been reported during treatment with other cephalosporins. Therefore, it should be recognized that a positive Coombs test could be due to the drug. The results of assays using red cells from healthy subjects to determine whether ceftibuten would cause direct Coombs reactions in vitro showed no positive reaction at ceftibuten concentrations as high as 40 µg/mL.

Hepatic Dose :